Here is a timeline of Djokovic's decline since the last of his 12 Grand Slam titles.
Djokovic received a lot of heat from the tennis community and fans alike after testing positive.
Grigor Dimitrov and Borna Coric tested positive for COVID-19 while participating in Novak Djokovic's Adria Tour exhibition tournament
Factbox on Rafael Nadal, who beat Novak Djokovic 6-0, 6-2, 7-5 on Sunday to win a record-extending 13th French Open title:
Coric's positive test follows that of Grigor Dimitrov, who said on Sunday he had contracted the novel coronavirus.
The tournaments involve eight players each, divided into two pools of four on a round-robin basis. Sets have been slashed to best-of-seven games.
Greek tyro Stefanos Tsitsipas' dream run at the Rogers Cup continued on Friday as the teenager toppled defending champion Alexander Zverev 3-6, 7-6(11), 6-4 to reach the semi-finals in Toronto.
Thiem, Wawrinka stay positive after defeats on return
The first meeting between Nick Kyrgios and Stefanos Tsitsipas lived up to the hype on Saturday as the Australian saved a match point in a wildly entertaining 6-4, 3-6, 7-6(7) win to reach the Citi Open final.
Check out some of the up-and-comers who could cause an upset at Wimbledon this year.
For the second time in three days at the ATP Finals, Rafael Nadal fought off one of the game's rising powers but beating Greek Stefanos Tsitsipas proved in vain as his semi-final hopes vanished on Friday.
Clearly Nikoloz Basilashvili had come to face Rafael Nadal with a plan but, like Mike Tyson said, everybody has a plan until they're punched in the face.
Rafael Nadal dropped a set at Roland Garros for the first time in two years but roared back to beat 10th seed Diego Schwartzman 6-3, 4-6, 6-4, 6-0 on Wednesday and storm into the French Open semi-finals.
Holger Rune crashed out to Yoshihito Nishioka in the ATP 250 Adelaide International 1 first round.
World number three Roger Federer is playing his first tournament on clay for three years as he prepares for the French Open.
Zverev was left wondering why he has been struggling to get into his matches
Alexander Zverev is a potential superstar who bears comparison not only with his fellow German Boris Becker but also the great American singer Bob Dylan.
The 34-year-old practised for an hour on Thursday evening at the Rod Laver Arena and his fitness was improving "little by little, step by step", sources close to Nadal told Reuters.
Nadal, 31, pulled out of the Paris Masters before his quarter-final match last week after experiencing discomfort in his right knee during his third-round win over Pablo Cuevas.
To the clear delight of the fans, however, Djokovic then bounded onto the court after his practice partner had won the first set and proceeded to wrap up a 6-3, 6-3 win over the Italian teenager.
Men's governing body ATP on Monday unveiled a revised system for calculating world rankings when the season resumes in August following a five-month suspension due to the COVID-19 pandemic. Traditionally the ATP rankings operates on a formula of 18 best results over 52 weeks but will now cover a 22-month period from March 2019 through December 2020.
The 33-year-old Swiss, ranked 261 in the world after two knee surgeries, served solidly throughout a one-sided contest on the slick centre court, easing past an opponent who struggled to cope with Wawrinka's power.
Stefanos Tsitsipas pulled off one of the biggest wins of his short but remarkable career by beating Rafael Nadal 6-4 2-6 6-3 on Spanish soil on Saturday to book his place in the Madrid Open final against world number one Novak Djokovic.
While Federer and Nadal will look to reignite the flair and fight they showed to reach last year's final, 2018 could have a different script at play.
Top singles player Yuki Bhambri on Monday returned to the Indian Davis Cup team along with Saketh Myneni even as veteran Leander Paes was expectedly dropped from the squad for the tie against Canada next month.
Nadal will not be playing at Wimbledon, having decided to rest, while eight-time champion Federer is showing signs that, at 39, the window of opportunity to win one more Slam is closing.
Czech defending champion Katerina Siniakova fended off Maria Sharapova in a fiercely contested match at the Shenzhen Open on Friday to set up a final with world number one Simona Halep.
Rafael Nadal withdrew from the Indian Wells tournament on Saturday with a knee injury, shortly before his eagerly-awaited semi-final clash with great rival Roger Federer.
Serena will not be in the US team for the Tokyo Olympics
Resurgent Spanish great Rafael Nadal will have the rare privilege of playing on a court named after him when he meets Brazilian Rogerio Dutra Silva in the last 32 of the Barcelona Open on Wednesday.
List of French Open men's singles champions:
Exodus of big guns opens up bottom half of men's draw
Greek teenager Stefanos Tsitsipas slayed another tennis giant on Saturday, saving a match point as he toppled big-serving Kevin Anderson 6-7(4), 6-4, 7-6(7) in a thriller to set up a Rogers Cup final against top seed Rafael Nadal.
Novak Djokovic ruthlessly took Matteo Berrettini apart at the ATP Finals on Sunday as he began his quest to reclaim the number one ranking by winning his opening group match 6-2, 6-1.
Penpix of the top men's contenders at the 2021 Australian Open
Six months on, with an Olympic silver medal in the bag, the Argentine beat 11th seed David Ferrer of Spain 7-6, 6-2, 6-3 to reach the US fourth round for the first time since 2012.
World No 3 Andy Murray remained on course for a first career clay court title.
The winners of the Serbia-Germany tie will join Spain, Russia and Italy in the semi-finals.
Rafael Nadal continued his quest for a maiden Paris Masters title when he survived a second set blip to beat Uruguay's Pablo Cuevas
Rafa Nadal's below-par season has continued with the former world number one dumped from the Rio Open semi-finals with a 6-7(6) 7-6(3) 6-4 defeat by unseeded Uruguayan Pablo Cuevas on Saturday. The top seed pipped Cuevas in a first set tie-break and denied his opponent two set points in the second but succumbed to his first defeat against the world number 45. "I lost an opportunity, that's it," Spaniard Nadal said after being denied his 100th ATP final by claycourt specialist Cuevas who fired 48 winners to clinch the contest. "I fought until the end. I have to accept it and keep working to try to change the dynamic. That's what's happening today and I have to work hard to change it," added the 14-times grand slam champion. "I didn't win a title, so it wasn't a positive two tournaments. I had my chances in both. I lost in the semi-finals of both tournaments and just have to look forward to Indian Wells."
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